Why this happens
Estradiol supports serotonin synthesis, receptor sensitivity and BDNF. Progesterone metabolites calm GABA. When these fluctuate, mood circuits destabilise — even in women with no prior depression.
Mood & Hormones
Low mood in perimenopause.
New onset depression in your 40s, especially around your cycle, is often hormonal. Estradiol modulates serotonin directly. Many women avoid years of trial-and-error SSRIs once hormones are addressed.
Serving Lowell, Fayetteville, Rogers, Bentonville, Springdale & Bella Vista — Northwest Arkansas
- Mood lifts
- Motivation returns
- Less crying
- Stable cycle moods
- Energy back
- Better relationships
Our approach
Full hormone panel, thyroid, B12 and vitamin D. BHRT, progesterone at night, thyroid optimisation, exercise, and SSRIs only when truly indicated — coordinated with your prescriber.
FAQ
Frequently asked questions.
+Should I stop my SSRI?
Never abruptly. Many patients taper successfully once hormones are dialled in — with their prescriber's help.
+How fast does this work?
Most women feel a real shift in 4–8 weeks.
Ready to feel like yourself again?
Book a one-on-one consultation with Dr. Tammy and get a personalized plan built around your labs, symptoms, and goals.
Questions? Give us a call.
Our staff would love to help you choose the service that's right for you.